Alpha Zeta Omega (ΑΖΩ or AZO) is an American co-ed, pharmaceutical professional fraternity founded on December 19, 1919.

Alpha Zeta Omega was formed for academic support; the original stated goal was to ensure 100% graduation of its members.

The first such affair took place at the Hotel Walton, Philadelphia in June 1922, with E. Fullerton Cook, chairman of the Pharmacopoeia Revision Committee, as guest and toastmaster.

After the Dead Men's Club founding members graduated, the group held its first official gathering at the home of Abe M. Bernstein.

In 1922, Alpha Zeta Omega Fraternity Supreme Chapter was officially incorporated under the laws of the State of Pennsylvania.

An emergency session of the fraternity was called and a support drive was held to assist those members' businesses that were damaged or destroyed in the flood.

In the early 1970s, AZO began admitting women as members for the first time and thus became a co-ed fraternal organization.

The Greek letters AZO were chosen to represent: The fraternity's pin was designed by A. M. Bernstein, D. L. Dyen, M. Shuman, and E. G. Sless.

The Achievement Medal is presented to a person (not necessarily a member) for "long and meritorious service to the Profession of Pharmacy".

The Order of the Double Star is awarded to members "who attain positions of respect and importance within the Profession of Pharmacy".

In honor of their late founder, the membership began a campaign to establish scholarships across the United States and in Israel.

After the events of September 11, 2001, AZO started a project to benefit the Dean Street Heroes Fund, N.Y. Fire Dept., Engine Co. 219.

After the devastation caused by Hurricane Maria to Puerto Rico, where one of AZO's chapters resides, a project was started to benefit the rebuilding of the territory.