Alphonse Desjardins, PC (French pronunciation: [alfɔ̃s deʒaʁdɛ̃]; 6 May 1841 – 4 June 1912) was born in Terrebonne, Canada East, and was mayor of Montreal from 1893 to 1894 and later a Canadian cabinet minister.

He owned a tile factory and participated in the founding of the Banque Jacques-Cartier, which later became part of the National Bank of Canada.

He represented the riding of Hochelaga in the House of Commons for 18 years, serving as a cabinet minister and Minister of Militia and Defence for a few months at the end of the Mackenzie Bowell government and then the short-lived Tupper government in 1896.

For a time he held all three posts (member of the House of Commons, Senator, mayor) simultaneously.

In 1872, he was created a Knight of the Order of Pius IX in acknowledgment of his services to the Catholic Church.