The community gained its name from Alpine, a plantation owned by the Welch family.

Initially known as Welchs Depot, it eventually came to be known as Alpine, in honor of the plantation.

[1] Alpine has never reported separately as an unincorporated community on the U.S. Census.

[4] In 1930 and 1940, when the census reported racial statistics for the precincts, it had a Black majority.

In 1960, the precinct was merged as part of a larger reorganization of counties into the census division of Sycamore-Winterboro.