Based on an all-aluminium construction, the A110 is powered by a Nissan-derived 1.8-litre turbocharged gasoline direct injection 4 valves per cylinder inline-four engine mated to a 7-speed dual-clutch transmission manufactured by Getrag.

The Première trim cars are technically the launch edition models which were limited to 1,955 units and were equipped with amenities such as forged alloy wheels, quilted leather Sabelt bucket sports seats, a reversing camera, and metallic blue exterior colour as standard.

The A110 S benefits from increased power output (from 252 to 292 PS (185 to 215 kW; 249 to 288 hp)) from its 1.8-litre turbocharged four-cylinder engine as well as stiffer springs, new anti-rollbars, dampers, and high performance brakes.

The ride height is lowered by 4 mm (0.16 in) and the car is fitted with special Michelin Pilot Sport 4 tyres having a stickier compound contributing to more grip on the tarmac.

[5] Aesthetic changes include flag motifs, orange brake calipers and optional matte grey paintwork and lighter Fuchs alloy wheels.

[8] The Alpine A110 R (which stands for "Radical") is a track-focused version that debuted on 4 October 2022,[9] featuring a redesigned body kit and a more aggressive chassis setup.

Among the carbon fiber components are the hood with dual air ducts, the 18-inch wheels, the engine cover, and the Sabelt Track monocoque seats.

Additionally, the A110 R features a stiffer suspension setup with adjustable dampers, allowing the ground clearance to be lowered by 10 millimeters (0.4 inches), and Brembo brakes with improved cooling.

In May 2021, following the collaboration for "Alpine F1 x Felipe Pantone", the French carmaker and the Argentinian artist revealed a new edition of the A110 with a custom paint job, with only three produced.

[35][36] Available to order from 17 March 2023 in France, the A110 San Remo 73 special edition, limited to 200 units, celebrates 50 years since the original A110 won at Sanremo, marking the manufacturer's first and only WRC title.

[39] The Alpine A110 SportsX is a concept car based on the A110 Pure, presented at the 35th edition of the International Automobile Festival in January 2020.

[50] This track-only version of the A110 utilizes the same chassis as the road car but has been modified to include a roll cage, adjustable suspension and racing brakes.

[53] This upgraded version of the A110 Cup comes with more power as well as revised aerodynamics highlighted by an extremely aggressive front splitter and a large rear wing.

[54] It is homologated by the FIA to Group R-GT specifications, its light aluminium chassis is derived from the Cup & GT4 versions and has 1.8-litre, 4-cylinder turbocharged engine delivering between 320 and 330 horsepower.

[56] Alpine will participate for the first time in its history on 25 June 2023, in the Pikes Peak International Hill Climb, using a special variant of the A110 developed in collaboration with Signatech.

"[citation needed] James May remarked on the Alpine A110, pronounced (‘Alpeen’), "It has 248bhp, weighs the square root of diddly, and is the greatest thing to come out of France since the Mouli cheese grater.

With Renault rebranding to Alpine for the 2021 Formula One World Championship, the brand introduced two cars exclusively used by drivers Fernando Alonso and Esteban Ocon to drive to the different tracks of the European leg of the season.