[8] In April 2020, Alpine Air Express purchased assets of the defunct Great Lakes Airlines which included 27 aircraft and various parts, engines, propellers and ground support equipment.

In October 1992, an Alpine Air PA-42 deviated off course and crashed into a mesa in Grand Junction, Colorado, while operating as an airtaxi flight.

August 2004 – While operating a Billings to Kalispell, Montana, flight for the US Postal Service, the Beech 99 crashed into Big Baldy mountain, located near Great Falls.

[10][11] January 2008—An Alpine Air Raytheon Beech 1900 crashed into the Pacific Ocean on a cargo flight between Honolulu International Airport and Lihue Intl in Hawaii.

[15][16] In February 2010, a cargo door came unlatched on an airborne Alpine Air Express Beech 99 carrying mail from Billings, to Kalispell, Montana, at about 1:30 a.m.

The plane was about 40 miles (64 km) north of Lewistown, Montana, when the pilot noted a light on the instrument panel had come on, indicating the door was unlatched.