The Alta Semita brought traffic into Rome from the salt route (Via Salaria) that had existed since prehistoric times.
[1] It ran most likely along the modern Via del Quirinale and Via Venti Settembre, on the spine of the Quirinal Hill, creating a straight route southwest from the Porta Collina in the Servian Wall to a major temple from the Hadrianic era on the Collis Salutaris.
[2] It may also be that the street called Alta Semita in the Roman Republic was not the same as the one known in the later Empire.
[3] The regional catalogues name Regio VI as Alta Semita, after the street.
[4] The temple of the Flavian family (Templum Gentis Flaviae) was located in Alta Semita, according to the regional catalogue.