The station is situated on the Gotthard railway north of its crossing of the Alps, and is the most southerly station before that line splits into the older route via Erstfeld and the original Gotthard Tunnel, and the newer route via the Gotthard Base Tunnel.

[4] Altdorf is a major hub for bus services in the Canton of Uri.

Auto AG Uri [de] operates local bus services to Schattdorf, Seedorf, Isleten, Isenthal, Unterschächen, Spiringen, Bürglen, Attinghausen, Erstfeld, Silenen, and Amsteg.

There are also two express bus services: the Tellbus Altdorf–Luzern [de] (operated by Auto AG Uri) to Lucerne, and the Winkelriedbus (operated by PostAuto Schweiz) to Stans.

[5] As of the December 2022 timetable change,[update] the following services stop at Altdorf:[6] Other InterCity and EuroCity passenger trains pass through the station without stopping, as does the considerable freight traffic on the Gotthard route.