In addition to appearing on CNN as a commentator, she is a co-host of the talk show The View, for which she received a nomination for a Daytime Emmy Award.

[10] After graduating from Bella Vista High School in 2007, Griffin earned a bachelor's degree in Journalism and Public Policy from Patrick Henry College.

"[8][7] In 2010, Griffin was a media intern for Congressman Tom McClintock and began a one-year position as an associate producer on The Laura Ingraham Show.

[12] In the 2012 presidential election cycle, Griffin was the spokesperson for the College Republican National Committee, traveling the country discussing the youth vote.

As press secretary to the vice president, she traveled with Pence on numerous trips, domestic and foreign, and was part of the official U.S. delegations to the Munich Security Conference and ASEAN Summit.

In April 2020, it was reported that Meadows, by then Trump's chief of staff, had considered bringing Griffin on as a White House press secretary.

[17] In August 2020, The Washington Post reported that Griffin played an important role in shaping the Trump administration's coronavirus response.

[19] The day before January 6, 2021, United States Capitol attack, Griffin publicly condemned Trump supporters for harassing Senator Mitt Romney.

In the editorial, which was published by USA Today, the two discuss the need to overcome the political divide in the U.S.[26] Griffin voluntarily spoke to the January 6 House select committee several times in 2021.