On October 16, 1923, he returned to his home town, where he painted the murals at Universidad de Guadalajara's assembly hall together with David Alfaro Siqueiros and Carlos Orozco after 1925.

Although details are unclear, it was noted that Amado de la Cueva, alongside Carlos Mérida, showed their work at the Madrid Autumn Salon of 1921.

[2] Soon after, in September 1922, Jose Vasconcelos, who was the minister of education at the time, brought back home David Alfaro Siqueiros and Amado de la Cueva from Europe to paint murals for him.

José Vasconcelos had assigned Amado de la Cueva (along with Carlos Mérida, Jean Charlot, and Xavier Guerrero) to assist Diego Rivera in painting the Bolívar Auditorium of the National Preparatory School.

Xavier Guerrero, Amado de la Cueva, and Jean Charlot decorated the second court of the ministry building, which they were originally assigned to at a salary of 12 pesos.

[4][3] De la Cueva left on 16 October 1923 for Guadalajara where José Guadalupe Zuno, who was the state governor at the time, was to give him murals to paint.

[2] De la Cueva was soon joined by David Alfaro Siqueiros at the end of 1924, and they were both offered a joint commission by state governor Zuno to paint the walls and ceiling of the former chapel beside the University of Guadalajara.

On 1 April 1926, Amado de la Cueva was involved in an automobile collision while riding his motorcycle around town along with his fellow painter Roberta Reyes Pérez, and died on the same night.

[2][3] At the former chapel of the University of Guadalajara, Amado de la Cueva and David Alfaro Siqueiros together painted several murals around the themes of Work and Rebellion.