Amago Kunihisa (尼子 国久, 1492 – November 25, 1554) was a Japanese warlord during the Sengoku period of western Honshu.
Under his father, he fought in campaigns in Aki and Bingo provinces during the 1520s and alongside Amago Haruhisa at the Siege of Koriyama Castle in 1540.
In 1544 he defeated a Mōri army but lost his second son, Toyohisa, at the bitterly fought Battle of Hashizugawa in 1546 against Takeda Kuninobu of Inaba Province.
One possible reason for Haruhisa's hostility towards Kunihisa and his Shingu faction is that they displayed increasing arrogance as their fame from their war service grew.
In 1554, Kunihisa was killed by Amago Haruhisa on the suspicion of treason on 25 November 1554 along with his eldest son Sanehisa and two grandsons, including a number of his retainers.