[6] Nguyen drafted the Sexual Assault Survivors' Rights Act, a bill that passed unanimously through the United States Congress.

[8][9][10] Nguyen has also been credited with kickstarting the movement to stop violence against Asian Americans after her video calling for media coverage went viral on February 5, 2021.

[15] Furthermore, Nguyen is featured in the 2022 anthology We Are Here: 30 Inspiring Asian Americans and Pacific Islanders Who Have Shaped the United States by Naomi Hirahara and published by the Smithsonian Institution and Running Press Kids.

[16] On February 27, 2025, it was announced that Nguyen would be part of the crew for Blue Origin's eleventh flight to space under the New Shepard program, along with Katy Perry, Aisha Bowe, Kerianne Flynn and journalists Gayle King and Lauren Sánchez.

[39] In November 2014,[40] Nguyen founded Rise, a nonprofit organisation which is aimed to protect the civil rights of sexual assault and rape survivors.

[29] Nguyen's aim is for Rise to pass a Sexual Assault Survivor Bill of Rights in all 50 U.S. states as well as on the national level.

[28][36] In July 2015,[35] Nguyen met with New Hampshire Senator Jeanne Shaheen to discuss legislation that would protect survivor rights on the federal level.

[4] On October 12, 2017, California governor Jerry Brown approved a bill titled "Sexual assault victims: rights".

[44] In 2018, Shepard Fairey created a portrait of Amanda Nguyen for Amplifier's "We the Future" campaign, a series of commissioned art pieces that were sent to 20,000 middle and high schools around the United States to teach about various grassroots movements.