Amani Abeid Karume (born 1 November 1948) is a Tanzanian politician, the former president of Zanzibar.

He is the son of Zanzibar's first president, Abeid Karume, and a member of the Chama Cha Mapinduzi (CCM) PARTY.

Karume returned to government and politics in 1990 when he was elected to the Zanzibar House of Representatives from the Raha Leo constituency.

Karume, running as CCM presidential candidate for Zanzibar, won 67.04% of the vote in an October 2000 election marred by irregularities and criticized by international observers (although polling on mainland Tanzania was generally praised).

It was the first time in the history of "democratic politics" of Zanzibar where the two leaders held dialogue to seek out a long lasting peace solution for the isles.