[3] Archaeological discoveries show a human presence in the area of Amatrice since prehistoric times, and the remains of Roman buildings and tombs have also been found.

After the fall of the Western Roman Empire, the area became part of the Lombard Duchy of Spoleto, included in the comitatus of Ascoli.

After the capture of Naples by the Angevins, Amatrice rebelled but was vanquished by Charles I of Anjou in 1274, although it maintained some sort of autonomy as an universitas.

After the unification of Italy in the 19th century, Amatrice became part of the province of L'Aquila in the region of Abruzzo, eventually being annexed to Lazio in 1927.

[5] Sergio Pirozzi, at the time the mayor of Amatrice (in March 2018 he was elected in the Regional Council of Lazio[6]), said that the town "is no more".