Launched on November 16, 2010, it took its current name on October 4, 2023 after its merger with MGM Holdings, which Amazon had acquired the year prior.

[5] Scripts for television and films used to be submitted online to Amazon[6] and read by staff; however, the website states they no longer accept submissions.

[7] If a developed script was selected for distribution as a full-budget movie, the creator was paid $200,000; if it was selected for distribution as a full-budget series, the creator was paid $55,000 as well as "up to 5 percent of Amazon's net receipts from toy and t-shirt licensing, and other royalties and bonuses.

[14] It contained a survey allowing Amazon to collect feedback to determine whether or not it was worthwhile to make the comic into a film.

[16] On July 27, 2017, it was announced that, starting with the December 2017 release Wonder Wheel, Amazon Studios would be its own self-distributing company.

[25] In January 2023, Critical Role Productions signed a multi-year overall television and first-look film deal with Amazon Studios.

[26] In March 2023, it was announced in response to the decision to release Air into theaters worldwide instead of Prime Video, that Amazon had shut down United Artists Releasing and folded the distributor's operations into MGM, making Creed III the first film to be distributed by the latter studio itself under Amazon's ownership.

[33] In December 2023, Amazon MGM Studios secured a deal with Games Workshop, the creator of Warhammer 40,000, to adapt its characters and stories for film and television.

[35] In March 2024, beginning with the Prime Video release of the remake of Road House, Amazon MGM Studios kicked off the centennial anniversary celebration of the founding of MGM with a "100 Years" logo variant appearing on all films produced and released by the studio throughout the year.

[37] In July 2024, the company announced the revival of United Artists after more than a decade of dormancy as a label, entering a multi-year partnership with Scott Stuber, former Chief of Film at Netflix and Vice Chairman at Universal Pictures.

[39] On February 20, 2025, Amazon MGM and Michael G. Wilson and Barbara Broccoli of Eon Productions announced its intentions to form a joint venture to manage the franchise rights to James Bond.

[41] In 2017, for Manchester by the Sea, Amazon Studios became the first streaming media service to be nominated for the Academy Award for Best Picture;[42] the film was nominated for a total of six Academy Awards, winning two: Best Actor for Casey Affleck and Best Original Screenplay for Kenneth Lonergan.