The title Amazon Women on the Moon refers to the central film-within-a-film, a spoof of science-fiction films from the 1950s that borrows heavily from Queen of Outer Space (1958) starring Zsa Zsa Gabor, itself a film that recycles elements of earlier science-fiction works such as Cat-Women of the Moon (1953), Fire Maidens from Outer Space (1955), and Forbidden Planet (1956).

The DVD release features an unreleased sketch titled "The Unknown Soldier", starring Robert Loggia with Ronny Cox, Bernie Casey, and Wallace Langham.

Some television broadcasts of the film featured the sketches "Peter Pan Theater" and "The French Ventriloquist's Dummy", which were not present in the theatrical version.

"[5] Janet Maslin of The New York Times, in a largely positive review, described the film as "an anarchic, often hilarious adventure in dial-spinning, a collection of brief skits and wacko parodies that are sometimes quite clever, though they're just as often happily sophomoric, too.

[5] "The film's best sight gags come from Robert K. Weiss, who deserves kudos for the inspired idiocy of his Amazon Women segments", was the opinion of The New York Times.