In 2022, Ruffin and her writing partner Jenny Hagel co-founded their production company Straight to Cards under their overall deal with Universal Television.

[2] While performing with her improv troupe at an event in Chicago, Ruffin met comedian and owner of iO Theater Charna Halpern.

After returning to the United States, Ruffin performed as part of The Second City in both Denver and Chicago, where she first met future Late Night co-writer Jenny Hagel.

In 2011, she moved to Los Angeles; joined the YouTube comedy group RobotDown featuring Jessica Lowe, Carlo Corbellini, and Davey Vorhes; and appeared on an episode of Key & Peele.

The show returned to Sacred Fools in September 2016 for a performance attended by parody target Billy Mitchell himself.

[18] Ruffin auditioned for the show in 2014 alongside Tiffany Haddish, Leslie Jones, Gabrielle Dennis, Nicole Byer, Simone Shepherd, and Bresha Webb.

", "Amber's Minute of Fury", "Jokes Seth Can't Tell" (with fellow writer Jenny Hagel), and "Point, Counterpoint".

[28] The show broke away from the typical late night structure, foregoing guests and focusing instead on topical sketches.

[4][5][6] In February 2021, it was announced that Ruffin was set to co-write the Broadway-bound musical adaptation of Some Like It Hot alongside Matthew Lopez.