He painted The Allegory of Good and Bad Government in the Sala dei Nove (Salon of Nine or Council Room) in Siena's Palazzo Pubblico.

It is known that Lorenzetti engaged in artistic pursuits that were thought to have their origins during the Renaissance, such as experimenting with perspective and physiognomy, and studying classical antiquity.

The earliest dated work of the Sienese painter is a Madonna and Child (1319, Museo Diocesano, San Casciano).

Three walls are painted with frescoes consisting of a large assembly of allegorical figures of virtues in the Allegory of Good Government.

The better preserved "well-governed town and country" is an unrivaled pictorial encyclopedia of incidents in a peaceful medieval "borgo" and countryside.

Annunciation, 1344 Lorenzetti's final piece, telling the story of the Virgin Mary receiving the news from the Angel about the coming of baby Jesus, contains one of the first uses of clear linear perspective.

This difference could be attributed to the patron's stylistic wishes for Madonna and Child, or could indicate Lorenzetti's evolution of style.

[8] This fresco is particularly well known for its realistic sense of depth within an architectural environment, due to Lorenzetti's compellingly rendered three-dimensional space.

Giorgio Vasari, in Lives of the Most Excellent, Painters, Sculptors and Architects wrote of Lorenzetti's intellectual abilities, saying that his manners were "more those of a gentleman and philosopher than those of an artist".

This highlights the increasing secularity in Sienese art at this time, of which Lorenzetti was a leading proponent, through the uniqueness of his painting style.