[2] Ambrosia confertiflorais a perennial herb reaching heights between 30 centimeters and nearly two meters with bristly, fuzzy green to brown erect stems.

The multilobed fuzzy leaves have blades which can be nearly 16 centimeters long and are borne on petioles with lobed, winglike appendages.

As in other ragweeds, the inflorescence has staminate (male) and pistillate (female) flower heads.

The pistillate heads yield one or two fruits which are burrs up to half a centimeter long and covered in short spines.

[3][4] Ambrosia confertiflora is native to much of northern Mexico (from Sonora to Tamaulipas) and the southwestern United States from California east as far as Kansas, Oklahoma, and central Texas.