Substitute hosts include Mike Emanuel, Aishah Hasnie, Gillian Turner, Shannon Bream, Trace Gallagher, Julie Banderas, Martha MacCallum, Jacqui Heinrich and Sandra Smith.

On March 23, 2009, America's Newsroom began broadcasting in high definition and moved to Studio J, the Election Night 2008 set used by the Fox News Channel.

In September 2020, Hemmer re-joined the program for the network's live coverage of the 2020 presidential debate in Cleveland, Ohio.

In January 2021, Fox News announced a new daytime programming lineup, bringing back founding co-anchor Bill Hemmer to the newscast, along with Dana Perino.

Sandra Smith was moved to the 1-3PM/ET time block to co-anchor a new afternoon newscast with former Chief White House Correspondent John Roberts entitled "America Reports."