With the staff that is a participant in regular international viper research events, the museum hosts a diverse collection of living rattlesnakes and an extensive library of study material and educational tools.

[4] In addition to rattlesnakes, the museum holds a live Gila monster, one of the few known venomous lizard species.

The museum also houses a large collection of snake-related artwork, artifacts, and memorabilia.

Craig Ferguson, host of The Late Late Show with Craig Ferguson, was given a snake mug from the museum's gift shop by actress Mary McCormack on 13 April 2009.

During the interview McCormack, who shot her TV show In Plain Sight in Albuquerque, told Ferguson that she and her daughters frequently visit the museum.