The American Midwest Conference (AMC) is a college athletic conference affiliated with the National Association of Intercollegiate Athletics (NAIA) with 12 member institutions located in Arkansas and Missouri in the United States.

The conference began as the Show-Me Conference in 1986, then changed to its current name in 1994, reflecting that its footprint had expanded beyond Missouri.

The American Midwest currently has twelve full members, all but one are private schools.

The American Midwest currently has one associate member, which is also a public school: The American Midwest had eleven former full members, all but one were private schools: The American Midwest had two former associate members, both were private schools: Full member (non-football) Associate member (sport)