The series stars Anna Friel, Peter Facinelli, Jake Robinson, Jim True-Frost, Treat Williams, Nate Mooney, Elena Kampouris, Daniella Pineda, Sadie Sink, Adewale Akinnuoye-Agbaje and Omar Ghazaoui.

[1][7][8] According to TV Insider, the main reason for the surprising last minute name change was that the awareness of the upcoming series was low, and that the retitling would offer "the opportunity to better market the show to middle-American audiences.

The site's critical consensus reads "With a been-there-seen-that premise and multiple muddled plots, American Odyssey can't escape the shadows of its superior predecessors in an age of solid spy/action television.

Michael Hogan in The Daily Telegraph wrote after the first two episodes had aired that "The programme wasn't without tense moments but the trouble was its scattergun plotting.

"[14] Ellen E. Jones of The Independent was less harsh, writing that "This new series starring Anna Friel as an American special-ops soldier really is global conflict for dummies, but that doesn't necessarily make for bad television.