[1] It is responsible for accrediting HLA typing laboratories internationally to maintain the quality standards for histocompatibility testing between donors and recipients, with UNOS and NMDP utilizing its service to inspect and determine whether laboratories complied to industrial practices.

[2] They also published the first CWD (common and well documented) allele list, encouraging researchers to compare genetic differences between populations.

[3] The society sponsors the American College of Histocompatibility and Immunogenetics (formerly the American College of Histocompatibility and Immunogenetics), and offers 5 levels of certification.

[4] The medical journal Human Immunology is published by Elsevier on behalf of the society.

The society also sponsors several awards in recognition of accomplishments and contributions to the field of histocompatibility and immunogenetics, including:[5]