[3] Later, third-party developers created various CPU expansion boards featuring higher-rated 68040, 68060 and PowerPC CPUs.

The NiCad backup battery is one of the most common causes of problems in an aging device that uses one because it has a tendency to eventually leak.

As a result, at launch the A4000 was compatible with many existing Amiga peripherals, such as MIDI devices, serial modems and sound samplers.

Later, in an effort to offer modern expansion options third-party developers created replacement expansion boards for the A4000 which provide PCI slots allowing use of higher performance and widely available PCI hardware, such as graphic, sound, and network cards.

The A4000 shipped with AmigaOS 3.0, consisting of Workbench 3.0 and Kickstart 3.0, which together provide a single-user multi-tasking operating system and support for the built-in hardware.

AmigaOS 4, a PowerPC-native release of the operating system, can be used with the A4000 provided a CyberStorm PPC board is installed.

Up to 256 on-screen colors in indexed mode 262,144 on-screen colors in HAM-8 mode Resolutions from: Horizontal scan rates of 15.60-31.44 kHz Vertical scan rates of 50–72 Hz 28–56 kHz maximum DMA sampling rate (dependent on video mode in use) Digital Domain used an Amiga 4000 for motion control effects in films such as True Lies, Apollo 13, and Titanic.