She is known for her presence on social media apps such as Instagram, as a fixture in the LGBT ball community, and for her role as Cotton in the Fox television series Star (2016–2019).

[5] Scott later left the show, stating that she was offended by the way the producers wanted her to behave, which she believed would have been an exploitation of her trans identity.

[6][7] Producers on Bravo later claimed the reason Scott was not on the show anymore was because her transgender identity was "not enough to make [her] interesting.

[10] At an event in Atlanta hosted by the Gay & Lesbian Association against Defamation (GLAAD), the GLAAD President, Sarah Kate Ellis, said that "Amiyah Scott is a talented actress and brilliant advocate who uses her voice to uplift transgender women of color and educate fans everywhere about transgender people and issues.

At a time when LGBTQ visibility in the South is critical to moving our community forward, we are proud to stand with women like Amiyah to promote messages of love and acceptance."