Amoeba Cleansing Syndrome is the second studio album from American R&B singer Joi.

[2] EMI soon delayed Amoeba Cleansing Syndrome set for a later release in 1997, for more songs with commercial appeal.

FreeWorld Records released two different promotional EPs for radio with a selection of songs from the album.

FreeWorld Records went out of business before "Amoeba Cleansing Syndrome" was set to be released.

[3] In 2002, the album was made available for purchase on CD or digital format via Joi's official website.