His younger sister, Faithful, was the mother of the nineteenth-century Presbyterian minister George Duffield.

[1][2] Amos Slaymaker was born at London Lands in Lancaster County in the Province of Pennsylvania.

He was a member of an association formed for the suppression of Tory activities in Lancaster County, Pennsylvania.

[7][8] Slaymaker was elected as a Federalist to the Thirteenth Congress to fill the vacancy caused by the resignation of James Whitehill.

[9][10] Slaymaker died in Salisbury on June 21, 1837, and was interred in the Leacock Presbyterian Cemetery in Paradise.