She became heavily involved in songwriting beginning in 1962, and her career took off when she won a contest in her native state with the song Hermosísimo Lucero.
In 1969, she moved to Mexico City to attend the National Music School, a department of the UNAM.
Shortly after, she released her first album De la mano del viento.
Amparo Ochoa visited Nicaragua as a distinguished personality who participated in the country's revolution anniversary in 1983.
She performed along with Gabino Palomares Maldición de Malinche, a popular and touching song; its lyrics criticize the cultural proneness of many Latin Americans to revere white Europeans while despising indigenous people, an attitude inherited from the times of the Spanish conquest.