Amphilestidae is a family of Mesozoic mammals, generally regarded as eutriconodonts.

They may form a paraphyletic or polyphyletic assemblage, though they share with gobiconodontids their similar tooth occlusion patterns and may be especially closely related to them.

[1] They occur from the Middle Jurassic to Cenomanian,[2] and have a distribution across Laurasia.

The putative amphilestid Tendagurodon is considered a non-amphilestid member of Amphilestheria along with the newly described Condorodon by Gaetano and Rougier (2012).

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