Holoclemensia is an extinct genus of mammal of uncertain phylogenetic placement.

It lived during the Early Cretaceous and its fossil remains were discovered in Texas.

The lower molars had a high protoconid, a small paraconid, and the hypoconulid and entoconid were close.

[1] First described in 1968 by Slaughter, Holoclemensia texana is only known from a few teeth found in the Trinity Formation, in Texas.

[4] Despite its uncertain classification, Holoclemensia was probably close to the point where Metatherians and Eutherians diverged from each other.