It declined after several foreign conquests and destructions, but emerged as an important city in the region and played a major role during the Greek War of Independence.

It is believed that the name Άμφισσα (Amfissa) derives from the ancient Greek verb αμφιέννυμι (amfiennymi), meaning 'surround', since the city is surrounded by mountains Giona and Parnassus.

According to the Greek mythology, Amfissa, the daughter of Macar, son of Aeolus, and mistress of the god Apollo, gave her name to the city.

During the Frankish occupation of Greece in the 13th century, Amfissa was captured by the king of Thessalonica, Boniface of Montferrat, and was renamed to La Sole; since then the city came to be called Salona in Greek.

Pausanias, in his work Description of Greece, mentions the existence of the tombs of Amfissa and Andraemon, and the temple of Athena on the acropolis of the town, with a standing statue of bronze, which was said to have been brought from Troy by Thoas.

The town's form of government was oligarchic, similar to that of Sparta, but, during the Pericles' era in Athens, some unsuccessful attempts to establish democracy took place.

In 426 BC, Spartan general Eurylochus, on his way to Naupactus, arrived to Delphi and sent a herald to Amfissa, in order to detach them from Athens and make the Amfissians leave him pass through their lands.

During the Third Sacred War, 356 – 346 BC, the Amfissians, who were allies of the Thebans, cultivated part of the Crissaean plain, which belonged to Delphi, and founded potteries in Kirra.

Then Aeschines, the Athenian deputy, contradicted the Amfissians, introducing their illegal actions in the sacred lands of the Oracle of Delphi before the Amphictyonic League, which called Philip II of Macedon to intercede.

In 245 BC, Aratus, the strategos of the Achaean League, attacked and damaged Amfissa, but the two leagues allied with the Roman general Titus Quinctius Flamininus against Philip V of Macedon, and after their win over the Macedonian king, Titus proclaimed Amfissa, among other cities, as an independent and tax-exempt polis, capital of Ozolian Locris, with its own Boule, Ecclesia and coins.

But when the Aetolians realised that Rome was to rule the Greek cities and asked Antiochus III the Great of Syria for help, the Roman general Manius Acilius Glabrio seized Lamia and advanced to Amfissa, where he conquered the Crissaean plain and besieged the town in 190 BC.

When Octavian founded the town of Nicopolis, in memory of his victory over Antony and Cleopatra in the battle of Actium, he drove Aetolians to populate it but the parts of them moved to Amfissa.

[7] Since the middle of the 9th century, new invaders, the Bulgars, raided the region of Phocis and sieged Amfissa several times, but the most damaging was in 996, when Samuel of Bulgaria destroyed the town and slaughtered its people.

In 1205, after the Fourth Crusade and the establishment of the Latin Empire, Boniface of Montferrat, the king of Thessalonica, conquered the region of Central Greece.

In the 18th century, Salona became the center of preparations for the war against the Ottoman Turks in Central Greece, due to its strategic location and its proximity to the klephts of Giona and Parnassus mountains.

In the Greek War of Independence, Salona was the first town of Central Greece to revolt under the leadership of Panourgias, Giannis Diovouniotis, Ioannis Gouras and its bishop Isaiah, who were in cooperation with Athanasios Diakos, Yannis Makriyannis and others originated from Phocis.