[7] One of the most important rebels of the Greek revolution, Bishop Isaias of Salona, fought for the liberation of Desfina until his execution by the Turks on 22 April 1821 and encouraged Athanasios Diakos for the battle of Alamana.

Also, Isaias gave the signal for the beginning of revolution of Central Greece at the region of Prophet Daniel.

In Desfina there is the Monastery of Honest Precursor which was distinguished at the revolution on 1821 as well as the very important Byzantine monument, the temple of Brigadiers near to the church of Saint Haralampos that dates to the 12th century.

A large employer in the area of Desfina is Aluminium of Greece, which has a production facility at nearby Distomo.

The square of Desfina is encircled by traditional cafes and taverns which offer a view of Mount Parnassos.