She then started on a voyage as a Liverpool-based slave ship in the triangular trade in enslaved people.

On 3 October, the Greenland whaler Amphitrite, Pagan, master, was the first vessel to enter the dock.

[2] Cosnachan (or Cosmacher) sailed Amphitrite (or Amphitut) from Liverpool on 16 June, bound for Bonny; she was legally allowed to transport up to 470 captives.

[6] Lloyd's List (LL) reported on 10 January 1800 that Amphitrite, Cochrane, master, had capsized at New Calabar, Africa.

[8] However, there were two Amphitrites of Liverpool that were engaged in gathering captives off the coast of Africa in late 1799, and both were lost.