He was the lead singer in the Thai rock band, Micro, before their split up, where he then began his solo career.

Amphol's songs (solo, and with Micro) include "Jai Sohm Sohm" ("Broken Heart"), "Ow Pai Loey" ("Take It"), "Bauk Mah Kum Diow" ("Tell Me One Thing") and "Sia Mai" ("Broken").

A compilation album featuring new Thai rock bands such as Clash, Zeal and Kala called Little Rock Project features songs by Amphol and Micro being covered by various artists.

Amphol had the title role in The Story of Nam Pu, directed by Euthana Mukdasanit, which was submitted by Thailand for Academy Award for Best Foreign Language Film.

Amphol won the best actor award at the Asia Pacific Film Festival for Nam Pu, an award he shared with Chow Yun-fat for Hong Kong 1941.