His main research topics are high-energy astrophysics, black holes, active galaxies, quasars, and astrobiology.

Wandel serves as a senior scientist at the Racah Institute of Physics at the Hebrew University of Jerusalem.

In the year 1998–1999 he was a visiting professor, on sabbatical at the Department of Astronomy at the University of California, Los Angeles (UCLA), where he taught four astrophysics courses.

In that year Wandel collaborated at UCLA on research of Active Galactic Nuclei together with Professor Math Malkan which produced three groundbreaking papers on the subject of massive black holes.

One of their articles,[1] which was the first to present the relationship between the mass and luminosity of massive black holes in active galaxies, was cited about 600 times.

A sample from his lecture "Life in Distant Worlds" seals the song "There is no space between us" by the Israeli rapper Tuna on his album "And now for the intergalactic part".

This study has become the accepted reference for the number of Esperanto speakers in the world and is even quoted by Ethnologue.

[6] In Wandel's view, as long as the current situation persists and the linguistic status quo prevails, preferring one national language over the others, there will be no room for widespread Esperanto as a language of communication and it will remain the domain of a relatively small user public.

Amri Wandel's article "Esperanto and the Problem of International Communication" appeared in the 2009 Hebrew Expression and Language Israeli state Examination.