She has appeared in television series such as Brooklyn Bridge, ER, and Being Human, and was nominated for a Screen Actors Guild Award for her role in Picket Fences.

[1] As of the late 1980s, her parents, Adele Frances Mesiti Aquino and Salvatore Aquino, lived in Carolina Beach, North Carolina, acting in bit and extra roles for production shot in the nearby town of Wilmington, such as From the Hip (1987), Date with an Angel (1987) and Windmills of the Gods (1988).

[6] In 1995, Aquino was nominated for a Screen Actors Guild Award for portraying Dr. Joanna "Joey" Diamond in Picket Fences.

[11] Aquino played college President Dalley in The Lazarus Effect (2015),[12] co-starring Sarah Bolger, Mark Duplass, and Olivia Wilde.

[13] Aquino starred in Amazon Studios' television series Bosch as Lieutenant Grace Billets.

[3] Together they purchased the Villa Royale, an inn in Palm Springs, California, which they renovated over a two-year period.