His other acting credits include Humpday (2009), The League (2009–2015), Greenberg (2010), Safety Not Guaranteed (2012), The One I Love (2014), The Lazarus Effect (2015), Togetherness (2015–2016), Blue Jay (2016), Tully (2018), Goliath (2018–2019), Paddleton (2019), and Language Lessons (2021).

For his portrayal of Charlie "Chip" Black in The Morning Show (2019–present), Duplass received two nominations for the Primetime Emmy Award for Outstanding Supporting Actor in a Drama Series.

[3][4][5] He was raised as a Roman Catholic,[6][7] and attended Jesuit High School, University of Texas at Austin, and City College of New York.

The two brothers later wrote, directed, and produced the films Baghead (2008) and Cyrus (2010) together[10] and have a unique style which consists of a great deal of ad-libbing off of the original script, shooting a number of takes, and editing scenes down 15 to 20 times.

That same year, Duplass co-starred with Evan Peters and Olivia Wilde in David Gelb's thriller film The Lazarus Effect.

[18] He also starred as real estate developer Tom Wyatt in Season 2 of the Amazon Video series Goliath.