She founded and led "Miss Best's" - the Central High School for Girls in Perth.
The Girls' College was a boarding school that the short-lived idea of the Bishop of Perth, Henry Parry.
[1] Parry was at the time successfully organising the construction of Perth's cathedral, but which was also facing financial issues.
[4] Best had created the St George Reading Circle in 1887 where women members could discuss current affairs and exchange ideas about books and literature.
In 2023 The West Australian newspaper identified the 100 people who had shaped the state of Western Australia and they included the botanist Georgiana Molloy, the educationalist Ursula Frayne, settler Emma Withnell, suffragist Bessie Rischbieth, politician Edith Cowan, Sister Margaret O'Brien, Dr Roberta Jull and Amy Jane Best noting that she had started the school and the Karrakatta Club.