"[5] Early in her career, Landecker primarily focused on stage work, including but not limited to Rajiv Joseph's All This Intimacy in 2006, and did not move to Los Angeles until she was 38.

[7] That performance received praise from many film critics, including Roger Ebert, who wrote, "Amy Landecker, too, is perfect as Mrs. Samsky.

She makes the character sexy in a strictly logical sense, but any prudent man would know on first sight to stay clear".

In 2014, she was cast alongside Jeffrey Tambor and Judith Light in the Amazon Studios comedy-drama series, Transparent.

[11][12] She co-starred in the Michael Bay-produced time travel thriller Project Almanac, which was released in January 2015.