Serrano attended Florida International University and graduated with a degree in Sociology and Anthropology with a focus on Latin-American and Caribbean Studies, Race and Ethnicity.

[3] Serrano executive produced the PBS broadcast Cafe con Leche: Voices of Exiles' Children.

[6] Narrated by Haitian-American author Edwidge Danticat and composed of field recordings coupled with outside testimony, the film explores the lives of the descendants of the first Africans delivered to the island of Hispaniola for the bittersweet commodity that once ruled the world.

"[3] The film's release resulted in multiple death threats against Serrano and persecution by Big Sugar and the Government of the Dominican Republic.

[7] Serrano's body of work includes directing and producing the short film Of Hope, Courage and Justice: A Global Mosaic of Women in Human Rights, and associate producing the Emmy-Award nominated Havana: Portrait of Yesteryear, narrated by Gloria Estefan, for PBS.

[10] In 2016, she was invited to write the foreword to photographer Diego Quiros' fine art photography book, Alchimie Photographique.

[13] Through poetry, short stories, song lyrics, art, and fine art photography, they join Amy to undertake the exploration of the beautiful complexity of this word that may be for an ardent desire, a deep seated longing, a bittersweet nostalgia, a haunting melancholy, a mysterious incomplete-ness, a desperate yearning, a poignant sadness, an elusive wish, an irreplaceable loss, a pervasive sense of missing-ness, and other nuances unraveled in the book.

[3] Serrano has been featured in Glamour Magazine [Spanish Edition] three times including Woman of the Year.