[8] She moved to Mexico City in 2002 at age 15 to join the reality show Pop Stars,[9] in which she was a finalist and member of a group, T'detila, who released an album with the same name.

[10] In 2003, she took acting classes in the Televisa's Centro de Educación Artística (CEA) in Mexico City.

[17] In 2013, she portrayed Maricruz Olivarez in the telenovela Corazón indomable, a remake of Marimar which achieved international success.

[24] Contreras starred as Goyita Vera in Blue Demon in 2016,[25] and as Alejandra Ponce in Por amar sin ley in 2018.

[26] From 2018 to 2019, Contreras starred as Cristal Jennings in the second season of The CW's prime time soap opera reboot, Dynasty, in her first English language role.

[30][31] Ana Brenda Contreras divides her time living between Mexico City and Los Angeles, where she develops her career as an actress.