Ana Ligia Mixco Sol de Saca (born December 1, 1961) is a Salvadoran businesswoman who served as the First Lady of El Salvador from 2004 to 2009.

The couple married on August 11, 1989, and had three children, Gerardo Antonio, Jose Alejandro and Christian Eduardo.

[1] In 2006, First Lady Ana Ligia Mixco de Saca served as the honorary chairperson of the organizing committee for Special Olympics' Latin American Games, which took place in San Salvador from March 28 to April 2, 2006.

[2] On January 5, 2021, both Ana Ligia de Saca and her husband, who was already serving a 10 year prison sentence after pleading guilty in September 2018 to separate corruption charged, were found guilty of illicit enrichment and were ordered to repay the El Salvador government $4.4 million.

[3] On June 4, 2021, Ana Ligia de Saca and her brother Oscar Edgardo Sol Mixco would be sentenced to 10 years in prison money laundering Friday and was ordered to repay $17.6 million to the El Salvador government.