From 2011 to 2014 she served as Spain's Minister of Health, Social Services and Equality in the Rajoy Cabinet.

On 26 November 2014 she resigned due to the involvement of herself and her husband Jesús Sepúlveda in the Gürtel case.

[2] Ana Mato has been the subject of controversy regarding her alleged involvement in the Gürtel case, but for years she continued to receive the backing of Prime Minister Mariano Rajoy.

[3] She has maintained, with the support of her ex-husband, that she was unaware of the origin of gifts to her household, including cars and vacations, which have been identified in investigations into alleged corruption.

[4] On 26 November 2014, Ana Mato resigned as Minister of Health, Social Services and Equality after she was summoned to court as a "participant on a lucrative basis" in the alleged corruption crimes.