Anagennisi Epanomi Football Club (Greek: Αναμορφωτικός Σύλλογος Αναγέννηση Επανομής) is a Greek football club based in Epanomi, Thessaloniki, Greece.

In the period 1971–1972, it won the Macedonia FCA and the Greek FCA Winners' Championship, as a result of which it was promoted to Betta Ethniki, where it remained until 1982, for ten seasons.

Twenty-nine years later, in the 2010-11 season, it won the championship of the northern group of the 3rd National Division, as a result of which it was promoted to the 2nd National League, where it remained for 2 years, until the 2012–13 season.

From the 2013–14 season and for 10 years, he competed in the amateur championships of Macedonia FCA.

In season 2022-23 finished second in Macedonia FCA championship and take a wild card from the Hellenic Football Federation[1] to participate in 2023–24 Gamma Ethniki.