The film is based on the concept of anamorphosis, a painting technique that manipulates the laws of perspective to create two competing images on a single canvas.
Dafoe turned down the role initially but reconsidered after a chance meeting with producer Marissa McMahon on a flight from Los Angeles.
Resigned to a teaching position for forensic psychology, he is called back to active duty following the elaborately staged murder of a man in a high-rise apartment building.
The victim is suspended and surrounded by photography lights, the room sealed off except for a pinhole, creating a projected camera obscura effect on the apartment wall.
A second killing quickly follows the first, in which the butchered corpse's limbs are hung independently from wires, creating the image of a raven when viewed from the proper angle.
Following this, Stan returns home to find his apartment has been broken into, the thief stealing an antique Victorian chair and replacing it with a taping of his inquiry following Crystal and Uncle Eddie's deaths.
The following morning, Stan is informed Ruiz has been found murdered, his abdomen opened and his innards removed, forming an inkwell of blood.
The next day, Stan receives a call from the killer, who repeatedly tells him "a poison harms" (An anagram for anamorphosis, the artistic technique he is using), and tells Stan to come see his next show, which is another empty warehouse containing diagrams of the final Uncle Eddie murders, including Crystal's, which, when viewed from high above, had the appearance of a body on a rock by a beach shore.
Stan, noticing the tattoo with an eye stenciled beneath it, places his head on Sandy's back, revealing that, when viewed in conjunction with the warehouse floor, spells out the word 'DEAD', a hallmark of the Uncle Eddie murders.
The site's critics consensus reads: "Thin on plot but heavy on academic references, Anamorph proves more derivative than terrifying.