Eristavi-Khoshtaria began as a teacher in her birthplace, Gori, where she founded a free school for peasant children and later established a women's organization Mandilosani (1913-4).
In the 1890s she was encouraged by the popular Georgian writer Akaki Tsereteli to move to Tbilisi to continue her work on original writings.
Her first novels, მოლიპულ გზაზე (On the Slippery Path, 1897) and ბედის ტრიალი (The Wheel of Fate, 1901), enjoyed recognizable success.
Being the first Georgian female writer who set her work from a feminine view and direct it at educated adults, Eristavi-Khoshtaria's novels and stories follow one pattern: they trace the career of a Georgian noblewoman, thrown into turmoil of the collapse of the old economic and moral orders in the mid-19th century, defending her ideals of free work and truthful love against a corrupt background and clay-footed heroes.
[1] Anastasia Eristavi-Khoshtaria was married to Dutu Megreli (Dimitri Khoshtaria) (1867-1938), an author of popular patriotic poems and children's stories.