He partook in almost all student movement about the Macedonian question as well as the antidynastic demonstrations against the rule of Otto, which led to the fall of the first royal dynasty.

While in Kastoria, Pichion developed strong educational activity, putting effort in the creation of Greek schools and their staffing.

At the start of 1888, 15 Kleisourans and more than 40 Kastorians together with Vogatsians mainly and Korytsans were arrested by the Ottoman authorities and finally led to the prisons of Monastir to be tried.

Anastasion Pichion took responsibility and in the end didn't lose his life because of the impact his arrest made internationally.

[3] Because of his activities he was imprisoned for six months in Monastir and later transferred to the fortress of Acre, from where he escaped to Athens with the help of the Greek deputy ambassador.