[4] Its mating call is a very loud, harsh chirping noise repeated many times, very fast.

The great plains toad feeds a range of insects such as lepidopterans, dipterans, hymenopterans, coleopterans, ants, and termites.

The great plains toad occur in deserts, grasslands, semi-desert shrublands, open floodplains, and agricultural areas.

Breeding takes place in temporary water bodies such as rain pools, flooded areas, and ponds; they can also use margins of reservoirs.

[1][3] The Great Plains toad has wide distribution and is not considered threatened, although it may suffer from road kills, farming, and suburban sprawl, increased droughts, and urbanization.