The SAS is part of the decentralised Spanish National Health System, and is funded through the annual budget of the Andalusian Autonomous Community.

As of 2019, the agency has more than 104,000 employees, including nurses, doctors, pharmacists, veterinarians, social workers, and administrative and service staff.

Drugs and prescriptions are subsidized, and people pay a percentage of the price depending on its incomes, with a monthly limit for unemployed and retired pacients.

The smallest geographical unit used in organizing primary care services are the districts known as zonas básicas de salud ("basic health zones").

[1] Specialty care provides the technical and human capabilities appropriate to diagnosis, treatment and rehabilitation for conditions that cannot be handled at the primary level.