Its range is nearly 5000 km away from the centre of the distribution area of the genus Phelsuma, in Mauritius and Madagascar.

In its home range, an immense genetic diversity of mitochondrial haplotypes is seen among individuals, indicating that it had colonized the Andamans entirely naturally and not due to humans somehow transporting it from the Western Indian Ocean islands.

[4][5] The body of this day gecko is bright green with red dots and stripes on the back.

Phelsuma andamanensis inhabits lowlands where is typically found in domestic gardens on coconut palms, screw pines, banana trees and on sisal plants.

This generalist lifestyle has allowed it to have a major population expansion with the growth of cash crops on the Andamans, making it a rare example of an island-endemic reptile that has actually massively benefited from anthropogenic disturbance.